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Infection may occur. Drug interactions _______________________________________________________ 657 Drug disposition in renal failure __________________________________________ 660 Absorption 661 Distribution 661 Metabolism 662 Excretion 662 Tissue sensitivity 663 Conclusions ____________________________________________________________ 663 References _____________________________________________________________ 664 Clinically overt nephrotoxicity is the result of the intrinsic capacity of a toxin to damage renal cells or tissue, the susceptibility of the patient, and changes in disposition of the toxin that result in increased de- livery to the target organ or tissue.

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